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KMID : 1141820210210010103
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Journal of Gastric Cancer
2021 Volume.21 No. 1 p.103 ~ p.109
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Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report
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Takahashi Keitaro
Ueno Nobuhiro
Sasaki Takahiro
Kobayashi Yu
Sugiyama Yuya
Murakami Yuki
Kunogi Takehito
Ando Katsuyoshi
Kashima Shin
Moriichi Kentaro
Tanabe Hiroki
Kamikokura Yuki
Yuzawa Sayaka
Tanino Mishie
Okumura Toshikatsu
Fujiya Mikihiro
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Abstract
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Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.
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KEYWORD
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GA-FGM, Gastric adenocarcinoma of fundic gland type, GA-FG, Helicobacter pylori, Eradication
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